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SCIENTIFIC COMMITTEE

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    Jacques P. Tremblay

    Université Laval, Canada
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    Illana Gozes

    Tel Aviv University, Israel
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    Leslie M. Shaw

    University of Pennsylvania, USA
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    Yuhua Song

    University of Alabama at Birmingham, USA

Jacques P. Tremblay

Université Laval

Canada

Professor Jacques P. Tremblay obtained a PhD in Neurosciences from Univ. of California in San Diego (UCSD) in 1974. He has been working on the development of cell and gene therapies for hereditary diseases since 1987. He has published 322 articles in peer-reviewed journals. He received the Henry Friesen Award from the Royal College of Physicians and Surgeons of Canada. He is currently using the Prime editing technology to correct mutations in the APP, DMD, RYR1, DYSF, MYOC and CFTR genes. He is currently trying to identify the best delivery method (AAVs, EVs, LNPs and VLPs) to deliver the components of the Prime editing technology.

Illana Gozes

Tel Aviv University

Israel

Professor, Tel Aviv University (TAU), formerly Lily and Avraham Gildor Chair and Director of the Adams Super Center for Brain Studies. Currently, Director, Elton Laboratory for Molecular Neuroendocrinology. B.Sc. TAU, Ph.D., Weizmann Institute of Science, postdoc. MIT and Salk Institute. Associate Professor, Weizmann Institute, Fogarty-Scholar-in-Residence, NIH, Humboldt Awardee, Germany. Mentored >80 students. Published ~400 papers (h-index 88 -Google Scholar). Inventor of multiple patents including the investigational drug Davunetide (NAP). Discovered ADNP, essential for brain formation implicated in autism, schizophrenia, Alzheimer’s disease and cancer. NAP is the neuroprotective site of ADNP. Received multiple awards for her scientific work.

 

Leslie M. Shaw

University of Pennsylvania

USA

Leslie Shaw, PhD, directs the Biomarker Research Laboratory and the Toxicology Laboratory at the University of Pennsylvania Medical Center in the Department of Pathology and Laboratory Medicine at the University of Pennsylvania Medical Center.  He is co-director of the ADNI Biomarker Core laboratory and has published more than 350 scientific papers and reviews in the peer-reviewed literature.  Dr Shaw has extensive experience in the development, validation and implementation of biomarker methods in clinical investigations especially multicenter studies.  He leads the bioanalytical and clinical validation of Alzheimer’s disease biochemical biomarkers, using advanced mass spectrometric and immunoassay platforms, for the ADNI study where his focus is on the most relevant CSF and plasma biomarkers for early detection, differential diagnosis, monitoring disease progression, and treatment efficacy in Alzheimer’s disease.  He is especially interested in identifying and controlling factors that contribute to biomarker measurement variability.  Dr Shaw is working collaboratively with other investigators on statistical strategies for combining biochemical and imaging biomarkers for best detection of Alzheimer’s disease.  He is also conducting studies in clinical trials of the effects of new treatments on Alzheimer’s disease biomarkers.  Dr Shaw co-leads the Biomarker Core of the PENN ADRC.  Most recently, he has overseen the successful validation and use in measurements of the plasma AD biomarkers Aβ42/Aβ40, ptau217, GFAP and NfL in  ADNI participants and in participants of the PENN ADRC, both sponsored by the NIA.

Yuhua Song

University of Alabama at Birmingham

USA

Dr. Yuhua Song is a Professor in the Department of Biomedical Engineering at The University of Alabama at Birmingham. Dr. Song’s research group uses integrated computational modeling and experimental approaches to investigate fundamental molecular mechanisms of protein structure and function, biomolecular interactions and to identify small molecules to regulate the biomolecular interactions underlying important cellular activities. Dr. Song is a biomedical researcher and has worked in computational modeling research for over 30 years. Dr. Song has published 59 peer-reviewed papers in quality journals including Neurotherapeutics, Alzheimer's and Dementia, Molecular Neurodegeneration, Frontiers in Neurology, Int. J. Biol. Macromol., J Biol Chem, Biophysical Journal, J Cell Biochem, Biochemistry, Proteins, Protein Science, and J Am Chem Soc

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